L-Theanine is an amino acid found in Camelia Sinensis (AKA green tea), which has a unique calming effect. Theanine modulates the glutamate system as well as altering the levels of monoamines (an increase in dopamine and serotonin) and GABA. Theanine is known for being calming but not to the extent that it will cause drowsiness, and is known to pair well with other stimulants.PMID: 31623400PMID: 9566605
Ashwagandha is a plant native to India which belongs to the nightshade species. Use of this plant goes back at least 6000 years ago as staple traditional medicine in India. It is known for its potent calming properties and features a wide array of benefits including but not limited to reducing inflammation, balancing blood sugar, improving memory, and boosting immune function. Ashwagandha’s mood effects are primarily through GABA/Glycine activation, as well as modulation of the serotonergic system.PMID: 22754076PMID: 37111543PMID: 24268297
Emoxypine, also known as Mexidol, is a bioactive compound originally synthesized in the Research Institute of Pharmacology in Russia, it functions as an antioxidant which resembles pyridoxine, also known as vitamin b6. Emoxypine features an impressive array of mechanisms including cerebral blood flow enhancement, anxiety reduction, anti-stress, anti-seizure, anti-inflammatory, and neuroprotection. Emoxypine’s ability to increase GABA sensitivity and its multitude of anti-inflammatory properties are thought to be responsible for its anxiolytic action. PMID: 25894772PMID: 11544797
Agmatine belongs to a class of compounds called Biogenic Amines and is also synthesized in the body from Arginine, an Amino Acid. Agmatine has the potential to reduce anxiety and depression-like symptoms and can also reduce pain and improve cognitive health. Its cognitive health promoting properties stem from its ability to provide neuroprotection in the form of antioxidant, anti-inflammation, and anti-apoptosis actions. Agmatine is also shown to reduce drug cravings to multiple drugs including alcohol, opioids, and amphetamines. Agmatine is also shown to have a rapid antidepressant effect via a similar mechanism achieved in ketamine therapy.
https://doi.org/10.1016/j.brainres.2020.147045
PMID: 36709008
PMID: 27161447PMID: 27232669PMID: 34888168PMID: 28786346
Lemon Balm, also known as Mellisa Officinalis, is a perennial belonging to the mint family, most commonly prepared as a tea. It provides anxiety relief and mood lifting effects. These properties are thought to be due to Lemon Balm's phytochemicals ability to inhibit the degradation of GABA, via its inhibition of GABA-Transaminase, the enzyme responsible for the breakdown of GABA. Lemon balm is also shown to possess high phenolic content and antioxidant properties. Lemon balm infusion improves plasma levels of catalase, superoxide dismutase, and glutathione peroxidase and a marked reduction in plasma DNA damage, myeloperoxidase, and lipid peroxidation. PMID: 25360512PMID: 34449930PMID: 27620926
Sabroxy is a patented extract standardized to contain a minimum of 10% oroxylin A, 15% baicalin, and 6% chrysin. The main focus of this standardized extract is oroxylin A, a dopamine reuptake inhibitor. Inhibiting dopamine’s reuptake in the brain causes extracellular dopamine not absorbed by the postsynapticneuron to be blocked from re-entering the presynaptic neuron. This leads to increased levels of extracellular concentrations of dopamine and increase in dopaminergic neurotransmission. Another example of a dopamine reuptake inhibitor is cocaine or methylphenidate (ritalin), although their effects are much more potent. Baicalin, also found in Chinese and American skullcap, is a flavonoid which increases gabaergic activity via acting as a positive allosteric modulator, which increases the receptor's response to endogenous GABA. Sabroxy is also shown to increase BDNF (Brain Derived Neurotrophic Factor), BDNF is responsible for neuroplasticity which is essential for learning and memory, and also regulates neurotransmitters. PMID: 26788077PMID: 34531736PMID: 35656442PMID: 18723037PMID: 23045656
Eria Jarensis is a not very well known plant that contains the phenethylamine compound known as NN-Dimethylphenethylamine (N,N-DMPEA), N,N-DMPEA is a ligand at TAAR1 similar to amphetamine, and also binds to the 5-HT1a receptor as an agonist, and was also shown to inhibit MAO-B, an enzyme that has an effect on the metabolism of dopamine downstream via GABA synthesis inhibition, which can increase the levels of dopamine. 5-HT1A receptor agonists may reduce the activity of serotonergic projections that inhibit dopaminergic nigrostriatal neurons, therefore increasing dorsal striatal dopamine levels.https://pubchem.ncbi.nlm.nih.gov/compound/N_N-Dimethylphenethylamine#section=BioAssay-Results
PMID: 15906386PMID: 34244591
B4 was custom formulated by a world-renowed biohacker for one purpose and one purpose only: social performance. It leverages a never-before-seen combination of nootropics to place you in a euphoric state of calm confidence.
B4 is meant to be taken 20-30 minutes before any social event such as work happy hours, a wedding, a date, or just heading to the bar.
Results vary consumer to consumer but, as a general rule, you can expect 4-5 hours of a calm, euphoric state.
To maintain effectiveness, we recommend taking B4 no more than 2-3x per week.
At this time we ship to the US only.